A BALB/c congenic strain of mice that carries a genetic locus (Ityr) controlling resistance to intracellular parasites.

نویسندگان

  • M Potter
  • A D O'Brien
  • E Skamene
  • P Gros
  • A Forget
  • P A Kongshavn
  • J S Wax
چکیده

BALB/c.DBA/2 Idh-1b-Ityr-Pep-3b congenic mice were developed by introgressively backcrossing the Idh-1b and Pep-3b markers of DBA/2 mice onto the BALB/c pi mice. This introduced a 30-centimorgan chromosome 1 segment of DBA/2 chromatin that contained the Ityr gene. BALB/c.DBA/2 Idh-1b-Ityr-Pep-3b mice were resistant to in vivo infections by Salmonella typhimurium, Mycobacterium bovis, and Leishmania donovani.

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عنوان ژورنال:
  • Infection and immunity

دوره 40 3  شماره 

صفحات  -

تاریخ انتشار 1983